I'll take on as many as I can answer.
1. Hand tight. You should be able to tighten it down until there's a 2-3mm gap between the base and the ring. Use a rag if the fittings are knurled, or your fingers will get chewed up a bit if you are doing all of them.
2. Yes, it's upside down. And yes, it matters with the Micro-res.
3. Mount it wherever you like. If it helps to shorten tube runs, I'd recommend moving it.
4. haven't used that block, can't help.
5. I'd run the tubing as follows: Pump to Rad, Rad to CPU, CPU to Res, Res to pump.
Sleeving and cable management looks good so far.