-You've got plenty of pumping power. Honestly, even a single 355 would be fine. An extra pump will give you redundancy and maybe a degree or two at most, but it's not going to work miracles.
-Generally not a good idea to mix pumps with significantly different pumping curves, and the 350 and 355 are quite different in their performance curves. If you're marginally handy with a soldering iron, one can be turned into the other, remember.
-The benefits of multiple loops are grossly overstated, and 90% water-peen, so I wouldn't worry about having fewer loops.
-Memory cooling? If you want, but it accomplishes nothing, while adding cost, complexity, and restriction to the loop.
-Very little performance loss from using 3/8 tubing instead of 1/2", and yes, it's much easier to route inside a case.
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