I think it really depends on the individual configuration and air flow of the case. While the set-up that you suggest sounds like it should provide the best solution, there is another way to look at it.
By pulling air past your rad into the case you will be introducing warmer than ambient temp air and also trying to force hot air (off of GPUs) downwards. A case can be made for trying to expell that hot rising air as quickly as possible and laterally pulling cooler ambient air into and across your GPUs.
Unfortunately, I believe that there's only one way to get a difinitive answer in your situation, and that is to try both ways under similar conditions. I know that I'm not much help kruzn. But if you do try the experiment, I would be interested in the results.
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