Getting the same problems but my Mass Effect games are retail, not Steam.

I think ATI video cards have a personal vendetta against me, given my history with them... I'm trying to get a Powercolor 4890 1GB to work, by the way.
Edit: Don't mean to hijack the thread, just contributing my own symptoms. I tried underclocking the card as low as I could within CCC's Overdrive and it fails the Custom Clocks test every time. I've never OC'd a GPU before so I don't know much about troubleshooting them. If you guys have any other suggestions I'd like to try everything I can on my own before going for an RMA.
Edit: I'm almost certain now this is a driver issue.