I run an x58 mobo which initially had 6gb (3x2gb, OCZ). I then bought a 12gb kit (3x4gb, Mushkin) which had different timings and put them in the three remaining slots. I did nothing special in the BIOS; it automatically downclocked all the RAM to the most limiting clocks (which was 1333 of the Mushkin sticks). If I really wanted to, I could have overclocked them all to 1600, but all in all, I don't see any significant improvements of 1600MHz (which I now run with 6x4gb, Mushkin) over 1333 (which I used to run with two different sizes of RAM sticks from two different manufacturers). Just my experience; YRMV.
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