I'm more concerned about the developer side of things. WPF/Silverlight/Win32/WinForms and .NET have been relegated as second class citizens and large quantity of developers (and clients) are miffed because of their heavy investment on these technologies (which were touted as Microsoft's "future" at some point). It's not what Microsoft is saying, but rather what they're not. While they've heavily emphasized the role of HTML5 to Window's future, they've almost kept mum about the rest of these technologies. This puts desktop/LOB applications, users and developers on the sideline in the aim for a more "profitable" future in the consumer space. Basically trading off their present and past consumers (desktop) for the tablet arena, which almost makes no sense. This is already starting to bite them in the ass as "nobody" seems to be rushing to produce XAML/HTML5/WinRT applications, which is probably the reason why they're de-emphasizing "legacy" desktop development in the first place; force developers to transition.
Maybe I'm looking at it at the wrong way, but I know a lot of technical leads and while there is no barrier for them to learn these new technologies (software evolves fast after all), some just feel too slighted by Microsoft and have the irrational feeling that Microsoft is out to screw with them. Heck, some even started buying apple, learning objective C and paying the $99/year developer subscription fee.
Personally, I wish the best of luck to Microsoft with Windows 8. Who knows I might just begin to like it at some point. A small part of me though (the irrational one) kinda hopes the whole things goes down to the fiery flames of hell, where it belongs.