I think the 2 GTX295's will suit you just fine. If you
really want to go mental then buy the i7 965 XE, it's the only upgrade I can see lasting you longer.
You should be fine for DX11, because it's coming out Q4 2009 at
best, which is very, very unlikely. Plus, it took almost a year after DX10's release for good DX10 games to be released for it, and most of those DX10 games released were able to run on DX9. Just as well, I heard that DX11 will work with DX10 cards anyway, they're trying to make it better than DX10 was. So if you get your 2 GTX295's, and DX11 comes out, it will:
a) Not work with DX10 cards, but at least it's a year before your card turns obselete, or at least buy DX11 games that can run in DX10 as well
b) Work with the GTX295 and you're good to go for the next few years.
As for your DVD drive. Don't worry about DVD drives. Just get a good, black, SATA 22x Dual Layer/DVD burner and you'll be fine. If games
really need to be more than one DVD, than for the next few years I can see them just using more than one, dual layer, overburnt DVD's. I can't see them standardizing blu-ray until they can sell them at $50 for a 100-pack, which is waaay far off.
From what I hear, the Antec 1200 is a suitable, but not that great case. I haven't owned one, but from what I've asked, it's loud, hard to work with, etc. If you want a full tower case (which is good), then get an:
HAF 932 ATCS 840 Silverstone TJ09 Silverstone TJ10
Of course, you could get anything that's full tower and Lian-Li, but that migh cost you a bit.