Go Back   Hardware Canucks > HARDWARE CANUCKS COMMUNITY > HardwareCanucks F@H Team

    
Reply
 
LinkBack Thread Tools Display Modes
  #1 (permalink)  
Old June 26, 2010, 01:05 PM
LCB001's Avatar
Folding Captain
 
Join Date: Feb 2008
Location: Aylmer QC.
Posts: 1,774

My System Specs

Default New Research Paper Published Using -bigadv Results

It's nice to see some results from all our hard work,

From FAH-Addict.net;

Quote:
Folding@home's 73rd peer-reviewed research paper was published today, in the journal PLoS Computational Biology. This paper used results from the p2681 -bigadv project, and is titled "Atomic-Resolution Simulations Predict a Transition State for Vesicle Fusion Defined by Contact of a Few Lipid Tails". The paper contains research on the process of Vesicle fusion, which is involved in the infection of cells by viruses, the transmission of impulses between nerve cells and cellular secretion.




Influenza


The summary of the paper is as follows:

Membrane fusion is a common underlying process critical to neurotransmitter release, cellular trafficking, and infection by many viruses. Proteins have been identified that catalyze fusion, and mutations to these proteins have yielded important information on how fusion occurs. However, the precise mechanism by which membrane fusion begins is the subject of active investigation. We have used atomic-resolution simulations to model the process of vesicle fusion and to identify a transition state for the formation of an initial fusion stalk. Doing so required substantial technical advances in combining high-performance simulation and distributed computing to analyze the transition state of a complex reaction in a large system. The transition state we identify in our simulations involves specific structural changes by a few lipid molecules. We also simulate fusion peptides from influenza hemagglutinin and show that they promote the same structural changes as are required for fusion in our model. We therefore hypothesize that these changes to individual lipid molecules may explain a portion of the catalytic activity of fusion proteins such as influenza hemagglutinin.
__________________
Folding For Team 54196

Reply With Quote
  #2 (permalink)  
Old June 26, 2010, 03:34 PM
stoanee's Avatar
Hall Of Fame
F@H
 
Join Date: Jun 2007
Location: Lacombe Alberta
Posts: 3,228

My System Specs

Default

I love to see results like that, gives an indication of the progress being made.
__________________
heatware
Reply With Quote
  #3 (permalink)  
Old June 29, 2010, 04:54 PM
0o0 0o0 is offline
Banned
F@H
 
Join Date: Oct 2009
Location: Toronto ON
Posts: 855

My System Specs

Default

hmm is there a summary of the summary? I'm still lost in the text =|
Reply With Quote
Reply


Tags
-bigadv , f@h , folding , new results , research

Thread Tools
Display Modes

Similar Threads
Thread Thread Starter Forum Replies Last Post
Innovation Cooling 7 Carat Diamond TIM Test results thread *NOW ACCEPTING RESULTS!!* Nademon Overclocking, Tweaking and Benchmarking 254 December 14, 2011 08:18 PM
IMPORTANT FOR BIGADV USERS: -bigadv workunits now require the 6.29 Linux SMP client Zero82z HardwareCanucks F@H Team 9 February 9, 2010 03:35 PM
Why F@H; Alzheimer's Simulation work published LCB001 HardwareCanucks F@H Team 13 December 19, 2008 08:21 PM
Anyone who wants to join one of my research projects? khelben1979 Off Topic 10 May 9, 2008 12:02 PM
Published Unklmo Off Topic 11 February 28, 2008 03:03 PM