I have an ATI card (4890) and quad core (q9550) with muticore rendering turn on and I don't have any problems. When you get into a situation with A LOT of zombies then you are going to wish you have muticore turned on. I use to be able to max out my e8400 (3.6Ghz) alot of the time but with a quad core at 3.6Ghz I usually hit about 50-60% each core.
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