I remember when HT was first introduced (Pentium 4 / Pentium D Extreme) some applications actually slowed down due to it being on, but that's rarely the case anymore.
I'd keep it on, unless your CPU is throttling because of the heat - check CPU-Z if the clocks drop after something (not necessarily the CPU) hits a certain temperature while stress testing.
This is on a socket 1155 CPU but here's a little idea of what HT can do for you:
http://www.tomshardware.com/reviews/...i5,2410-5.html
Essentially it will boost performance in applications that can't get enough threads, like transcoding, rendering, image editing, etc. Games have barely started to use 4 threads, and even then they don't use all four to their maximum effect.