Well in concept, it depends on what OS is being used, windows 7 and vista are both software driven audio cues, so even if you have onboard or a soundcard, it is by and large being driven first by windows then cpu to direct it sort of speak then finlly shifted to the hardware being the chips or soundcard. The difference is almost negligable in windows 7/vista because the HAL layer was removed, but this is also good, because you generally do not suffer performance penalties just overall sound quality instead.
Windows XP and prior and possibly other OS on the other hand, do treat audio directly where the cpu has to crunch it all, if there is proper sound hardware to deal with it, it will intercept the stream and handle it for much less performance hit then letting the cpu do it itself.
Now, like I said, I know windows 7 and soon to be 8 are all more or less software driven which feeds to whatever hardware you have, it is not the best thing really, as things did sound alot more "lively" before, but, you can still tell the difference of a good quality soundcard vs run of the mill onboard, not in a performance side, but most certainly in an audio quality side, sounds are just more pronounced, bass, sharp, however you want to look at it.
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