Kaperspy + Spyware Blaster + Spybot keep me nice and safe.
Getting rid of windows firewall would be nice, but I'm too lazy to configure my routers firewall
I've used Norton, McAfee, Avast, AVG, Nod 32, Kaperspy and some more and Kaperspy has been the best to me out of all of them. Though I do find it a little paranoid... OMG! a program called CPUz is trying to run, it MUST be spyware...