You may be right about an interference problem. If the wireless keyboard/mouse runs at 2.4 Ghz, that's the same frequency as wireless network adapters and older cordless phones. Thats why I bought new DECT phones, I had interference problems with my wireless-G setup.
I did try a wireless MS setup about a year and a half ago and kept getting my ass handed to me playing BF2142 as there was a definite input lag, so I went back to a corded desktop for gaming.
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