i'll second what DeadThings says. folding is folding, If you don't have a strong need for maximum points then SMP under windows still does good, if you aren't going to switch to linux then windows smp is your best bet.
I can't comment on scaling I haven't tried any testing myself, but from the reading I've done it all supports what has been said already.
in regards to memory, the linux bigadv units take about 3-5GB (48 core bigadv with 32gb ram) while the linux smp units take about 550MB (total system memory taken from a dual lga771 system with 8gb ram)
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