As was mentioned above, most modern gaming cases these days have provisions for many locations of fans and rads. I forsee an H100i on the top panel of a case, one ARESII blowing out the back panel, and one ARESII blowing up from the bottom. Or some variation of this.
And, the little 80mm fan wouldn't have to blow that fast. It's just to cool the VRM's and Heatsinks, and TBH I don't think those require that much cooling. That little fan is just to get some semblance of air movement over those components.
Although, Why ASUS wouldn't try to go with a full cover water block hooked up to the AIO system, and try to go for a single slot card, is beyond me. That would be a much more attractive solution, especially for the money you'll likely pay for this beast.
__________________  My Rig: Z77A-G45; 3570K; H80i; 2x4GB Kingston HyperX 1600Mhz; ASUS GTX660 SLI; 2x 128GB Crucial M4 SSD; 500GB WD Black; PC&C 750W PS; CM 690II Advanced;
Son's Rig: M5A97; 1055T; CNPS20LQ; 2x4GB Corsair Vengeance 1600Mhz; Sapphire HD5870; 80GB Intel 520 SSD; 320GB WD Black HDD; SPI 700W; Bitfenix Shinobi;
HTPC: F1A75-M PRO; A6 3670K; Hyper 212+; 2x4GB G.Skill Ripjaws 1866Mhz; ASUS GTX650Ti Boost; Corsair 60GB SSD; 1TB WD Green; 2x 2TB WD Green; SPI 450W;
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