Of course,any GPU uses a PCIe slot. 2.0 or 3.0 it's not important!Won't change anything, as long as you have one, it will work!Just plug the card in the highest slot ,so u make sure it's the x16. for the company,i recommend ASUS or MSI,or gigabyte. or course you could buy a cheap gainward or PNY or something like that but well, you won't have an awesome cooling :/They are not the best at all.
for a 680 i'd go for ASUS...or MSI, don't really know,you could get a lighting edition from MSI, more expensive, but the best 680 on the market, probably...
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