I leave all my PCs running 24/7 (except for when I go on vacation and my laptop which I put to sleep mode) most do folding for various teams. The only thing that I would see wearing out relatively quickly are HDDs and fans(water cooling pumps as well). I have had multiple fans in the past fail after 24/7 use, mainly sleeve bearings, but that was solved by using ball bearing fans. So basically any part of your pc that physically moves will usually wear out the fastest.
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