My first high performance build?
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August 21, 2012, 09:11 PM
Join Date: Jun 2007
If the external drive is connected with eSATA/USB 3.0/Thunderbolt, then sure, you can run applications off it without any connection bottlenecks. I think you'd have to manually enable write-caching in the drive properties for proper performance. You'd also want to partition it so that the applications are confined to the fastest part of the disk and are not fragmented across 3TB with data.
Why would you want to, though, with such a spacious case for internal drives that would be better cooled? Unless, maybe, you plan to switch between computers using those applications?
You might experience software errors or corruption if the external drive drops out while applications on the drive are running, or if it's assigned a different drive letter in the process of disconnecting/connecting it and other storage devices.
You can do anything you want, but I wouldn't go with that setup, especially if the 3TB is used for data/backup.
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