 Folding@home
folding is perfect for GPUs because it requires millions of easy calculations, for thousands of small processors (relatively speaking of course). I imagine that the GPU based CPU would start to falter when hit with programs that use harder math (know nothing of programing, so can't give examples.
that said, using 4x xfire to get 1280 cores would be cool, if only for the stats page.
[edit] also makes me wonder how GPU makers profit when they sell such a more complicated product, with onborard RAM and the whole deal for around $250 (8800gt), the price of an e8400, give or take.
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