i've had my antec 300 for a little over a month, 2 intake fans in the front running at 5V, two exhaust fans in the back running at 5V, and the side vent unblocked. it sits on the carpeted floor in my closet (it's a fileserver), and gets clothes piled around it, and there is no dust to speak of inside the case. i don't think you need to be too worried about dust.
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