I've been using a Sharp LC32D64U for about 5-6 months now as my sole display. Only issue that I know of if using VGA it will only go as high as 1600x1200 (who really would use VGA anyways?).
Once you get use to the text being larger it really is easier on the eyes.
In all seriousness I don't think I'll ever go back to a monitor.
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